Ascomycin

Synonyms: Immunomycin, FK520, FR-900520

Ascomycin is a macrolide immunosuppressant antibiotic. It is an ethyl analog of FK506. Ascomycin binds to the FK-506-binding protein FKBP12 and blocks the peptidyl-prolyl cis-trans isomerase activity of the protein. This bound complex inhibits calcineurin phosphatase in the nM range, consequently suppressing the presentation of Th1 and Th2-type cytokines in cells and reducing production of interleukins IL-2, 4, and 10, leading to immunosuppression. Pimecrolimus, an Ascomycin derivative, has been shown to block the release of allergic response mediators from mast cells.

Warning: For laboratory use only. Not fit for agricultural, household, clinical use or human consumption.

Technical specifications:

• Density: 1.19 g/cm³
• Melting Point: 153-157°C
• Boiling Point: 868.3°C at 760 mmHg
• Flash Point: 478.9°C

• Solubility: Soluble in methanol, ethanol, acetone, ethyl acetate, chloroform; slightly soluble in n-hexane and petroleum ether; insoluble in water