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Description

Fractionated Vicia villosa lectin or agglutinin (VVL/VVA) is a tetramer composed of four subunits. VVL consists of A and B subunits, with a dominant isolectin that appears to be B subunit-rich. A4 isolectin agglutinates specifically A1 erythrocytes. B4 isolectin does not agglutinate A, B, or O-erythrocytes; however, B4 binds the Tn antigen, a molecule expressed on the surface of most tumor cells. A2B2 and similar tetramer isolectins display properties characteristic of both A4 and B4 isolections.

Storage Instruction: To prevent degradation and avoid repeated freeze-thaw cycles, aliquot your product into small, single-use volumes and store them at -20°C

Properties

Shelf life

2 years

Storage Temperature

-20°C

ECCN #

EAR99

Appearance form

Lyophilized Powder

Molecular Weight

139 kDa

Abbreviation (Lectins Only):

VVL/VVA

Source

Hairy Vetch Seed

Blood Group Specificity

A subunit - A, B subunit - Tn antigen

Carbohydrate Specificity

GalNAc

Conjugate/Tag/Matrix

None

Inhibitory Carbohydrate

GalNAc

Divalent Ions

Ca++, Mn++

Cancer Biomarker

Pancratic and Gastric Cancer

Mitogenic Activity

None