Cloxacillin::BSA Conjugate

Cloxacillin Sodium is the sodium salt of cloxaclliin, a semisynthetic beta-lactamase resistant penicillin antibiotic with antibacterial activity. Cloxacillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall, thereby preventing the cross-linkage of peptidoglycans, which are critical components of the bacterial cell wall. This leads to an interruption of the bacterial cell wall and causes bacterial cell lysis.

BSA (bovine serum albumin) is conjugated to cloxacillin via the carboxyl group on the antibiotic and the amine group on the BSA. The resultant conjugation solution is then buffer-exchanged with 20 mM PBS at a pH of 7.4.

Conjugated BSA-cloxacillin is used to recognize cloxacillin-specific antibodies by ELISA and lateral flow based immunoassay. Product can be stored below -20°C for up to 3 years.