Annexin A5, Sf9 Human (Recombinant)

Synonyms

PP4, ANX5, ENX2, ANXA5, Annexin A5, Annexin-5, Annexin V, Lipocortin V, Endonexin II, Calphobindin I, CBP-I, Placental anticoagulant protein I, PAP-I, Placental anticoagulant protein 4, Thromboplastin inhibitor, Vascular anticoagulant-alpha, VAC-alpha, Anchorin CII.

ANXA5 is a member of the annexin family of calcium-dependent phospholipid binding proteins which are involved in membrane-related activity along exocytotic and endocytotic pathways. ANXA5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel properties and takes part in cellular signal transduction, inflammation, growth and differentiation. ANXA5 is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. ANXA5 regulates coagulability in the blood stream by binding to phosphatidylserine and sulfatide. ANXA5 protects sinsuoidal endothelial cells from ischemia reperfusion damage. ANXA5 is necessary for normal CFTR chloride channel activity.

Description

ANXA5 Sf9 is a full-length cDNA coding for the human Annexin V proteinhaving a molecular mass of 37,049 Dalton (pH 5.3). ANXA5 Sf9 protein is fused to a hexa-histidine purification tag.

Source

Sf9 insect cells.

Formulation

ANXA5 Sf9 (1.33mg/ml) is supplied in 20mM HEPES buffer pH-7.5, 250mM NaCl and 20% Glycerol.

Immunological function

Binds IgG-type human auto-antibodies.

Immunological tests

Standard ELISA test (checkerboard analysis of positive/negative sera panels); immunodot test.

Applications

Western blot withmonoclonal anti-Annexin V antibodies ormonoclonal anti-hexa-His-tag antibody.

Storage Conditions

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.

Usage

Bio-world products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

ANXA13 Human, ANXA5 Human