Bax Mouse (Recombinant), GST

Synonyms

Apoptosis regulator BAX membrane isoform alpha, Bax, Bcl2-associated X protein.

Bcl-2–associated X protein (Bax) belongs to the Bcl-2 protein family. Bax is a pro-apoptotic Bcl-2 protein containing BH1, BH2 and BH3 domains. Bax accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor bcl2 or its adenovirus homolog e1b 19k protein. Bax induces the release of cytochrome c, activation of casp3, and thereby apoptosis. Bax is expressed in a wide variety of tissues, with highest levels in the testis and ovary. Tumor suppressor protein p53 upregulates the expression of BAX. Bax has been shown to be involved in p53-mediated apoptosis.

Description

Bax Mouse Recombinant amino acid 1-171 produced in E. coli is a single, non-glycosylated polypeptide chain. The Mouse Bax is purified by proprietary chromatographic techniques.

Source

Escherichia coli

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The 1mg/ml protein contains 10mM Tris-HCL pH-8, 1mM EDTA and 150mM NaCl, 10% glycerol, 0.1% tween & 10mM glutathione.

Stability

Mouse Bax although stable at 12°C for 1 week, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles.

Usage

Bio-world products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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