Bax Mouse (Recombinant)

Synonyms

Apoptosis regulator BAX membrane isoform alpha, Bax, Bcl2-associated X protein.

Bcl-2–associated X protein (Bax) belongs to the Bcl-2 protein family. Bax is a pro-apoptotic Bcl-2 protein containing BH1, BH2 and BH3 domains. Bax accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor bcl2 or its adenovirus homolog e1b 19k protein. Bax induces the release of cytochrome c, activation of casp3, and thereby apoptosis. Bax is expressed in a wide variety of tissues, with highest levels in the testis and ovary. Tumor suppressor protein p53 upregulates the expression of BAX. Bax has been shown to be involved in p53-mediated apoptosis.

Description

Bax Mouse Recombinant amino acid 38-171 produced in E. coli is a single, non-glycosylated polypeptide chain. The Mouse Bax is purified by proprietary chromatographic techniques.

Source

Escherichia coli

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The protein contains 10mM Tris-HCL pH-8, 1mM EDTA and 250mM NaCl.

Stability

Mouse Bax although stable at 12°C for 1 week, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles.

References

1.Title: Bax Regulates Production of Superoxide in Both Apoptotic and Nonapoptotic Neurons: Role of Caspases.
Publication: The Journal of Neuroscience, 1 December 2010, 30(48): 16114-16127; doi: 10.1523/?JNEUROSCI.2862-10.2010 The Journal of Neuroscience, 1 December 2010, 30(48): 16114-16127; doi: 10.1523/?JNEUROSCI.2862-10.2010
Link: http: //www.jneurosci.org/content/30/48/16114.full.pdf

2.Title: Interaction of Insulin-like Growth Factor-binding Protein-3 and BAX in Mitochondria Promotes Male Germ Cell Apoptosis
Publication: First Published on November 3, 2009, doi: 10.1074/jbc.M109.046847January 15, 2010 The Journal of Biological Chemistry, 285, 1726-1732.
Link: http: //www.jbc.org/content/285/3/1726.full

Usage

Bio-world products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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