Chloride Intracellular Channel 1 Human (Recombinant)

Synonyms

ACBP, ACBD1, CCK-RP, EP, CLIC1, G6, NCC27, Nuclear chloride ion channel 27, Chloride channel ABP, Regulatory nuclear chloride ion channel protein, hRNCC, Chloride intracellular channel protein 1.

Chloride channels are various group of proteins that control fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, regulation of intracellular pH, and maintenance of cell volume. CLIC1 is part of the p64 family and is localized to the cell nucleus. CLIC1 displays both nuclear and plasma membrane chloride ion channel activity. CLIC1 inserts into membranes and forms chloride ion channels. CLIC1 channel activity depends on the pH. CLIC1 membrane insertion is redox-regulated and happens under oxydizing conditions.

Description

CLIC1 Human Recombinant produced in E. coli is a single, non-glycosylated, polypeptide chain containing 261amino acids (1-241a.a.) and having a molecular mass of 29 kDa. CLIC1 protein is fused to a 20 amino acid His tag at N-terminus and is purified by standard chromatography.

Source

Escherichia coli

Physical Appearance

Sterile filtered colorless solution.

Formulation

CLIC1 Human solution containing 20mM Trsi HCL pH-8, 0.1M NaCl & 10% glycerol.

Stability

CLIC1 Human although stable at 4°C for 1 week, should be stored desiccated below -18°C. Please prevent freeze thaw cycles.

Amino acid sequence

GSSHHHHHH SSGLVPRGSH MAEEQPQVEL FVKAGSDGAK IGNCPFSQRL FMVLWLKGVT FNVTTVDTKR RTETVQKLCP GGQLPFLLYG TEVHTDTNKI EEFLEAVLCP PRYPKLAALN PESNTAGLDI FAKFSAYIKN SNPALNDNLE KGLLKALKVL DNYLTSPLPE EVDETSAEDE GVSQRKFLDG NELTLADCNL LPKLHIVQVV CKKYRGFTIP EAFRGVHRYL SNAYAREEFA STCPDDEEIE LAYEQVAKAL K

Usage

Bio-world products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

CLIC2 Human, CLIC4 Human