Hepatitis C Virus NS3 GenoType-2b�(1192-1459), (Recombinant)

Recombinant Hepatitis C Virus nonstructural protein NS3 Subtype 2b (1192-1459)

Source: E.coli

Background: HCV is a small 50nm, enveloped, single-stranded, positive sense RNA virus in the family Flaviviridae. HCV has a high rate of replication with approximately one trillion particles produced each day in an infected individual. Due to lack of proofreading by the HCV RNA polymerase, the HCV has an exceptionally high mutation rate, a factor that may help it elude the host's immune response. Hepatitis C virus is classified into six genotypes (1-6) with several subtypes within each genotype. THe preponderance and distribution of HCV genotypes varies globally. Genotype is clinically important in determining potential response to interferon-based therapy and the required duration of such therapy. Genotypes 1 and 4 are less responsive to interferon-based treatment than are the other genotypes (2,3,5, and 6).

Description: The protein contains immunodominant region, amino acids 1192-1459.

Purification method: Purified by proprietary chromatographic technique.

Purity: Recombinant HCV NS3 is >95% pure as determined by 10% PAGE (coomassie staining).

Formulation: 1.5 M urea, 25mM Tris-HCl pH-8, 0.2% Triton-X & 50% Glycerol.

Storage: Recombinant HCV NS3 is shipped at ambient temperature. Upon arrival, Store at -20C.

Stability: Recombinant HCV NS3 is stable 5 years frozen, One month in solution at room temperature.

Specificity: Immunoreactive with sera of HCV-infected individuals

Application: Recombinant HCV NS3 Antigen may be used in ELISA and Western blots, excellent for detection of HCV with minimal specificity problems.

Usage: BioWORLD's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.