Hepatitis C Virus NS3 GenoType-5a, (Recombinant)�

Recombinant Hepatitis C Virus NS3 Genotype-5a

Source: E.coli

Background: HCV is a small 50nm, enveloped, single-stranded, positive sense RNA virus in the family Flaviviridae. HCV has a high rate of replication with approximately one trillion particles produced each day in an infected individual. Due to lack of proofreading by the HCV RNA polymerase, the HCV has an exceptionally high mutation rate, a factor that may help it elude the host's immune response. Hepatitis C virus is classified into six genotypes (1-6) with several subtypes within each genotype. The preponderance and distribution of HCV genotypes varies globally. Genotype is clinically important in determining potential response to interferon-based therapy and the required duration of such therapy. Genotypes 1 and 4 are less responsive to interferon-based treatment than are the other genotypes (2, 3, 5 and 6).

Description: E.coli derived recombinant from HCV subtype 5a. The protein contains the full-length HCV NS3 (c33c) immunodominant region.

Purification method: Purified by proprietary chromatographic technique.

Purity: Recombinant HCV NS3 is >95% pure as determined by 10% PAGE (coomassie staining).

Formulation: 25mM Tris-HCl, 1mM EDTA, 1.5M urea & 50% glycerol.

Storage: Recombinant HCV NS3 is shipped at ambient temperature. Upon arrival, Store at -20°C.

Stability: Recombinant HCV NS3 is stable 5 years frozen, One month in solution at room temperature.

Specificity: Immunoreactive with sera of HCV-infected individuals

Application: Recombinant HCV NS3 Antigen may be used in ELISA and Western blots, excellent for detection of HCV with minimal specificity problems.

Usage: BioWORLD's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.