High-Mobility Group Nucleosome Binding Domain 1 Human (Recombinant)

Synonyms

HMG14, GC104230, High-Mobility Group Nucleosome Binding Domain 1.

HMGN1 binds to the inner side of the nucleosomal DNA therefore changing the interaction between the DNA and the histone octamer. HMGN1 participates in the development which maintains transcribable genes in an exceptional chromatin conformation. HMGN1 inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2.

Description

HMGN1 Human Recombinant produced in E. coli is a single, non-glycosylated, polypeptide chain containing 108 amino acids (1-100 a.a.) and having a molecular mass of 11.7 kDa. HMGN1 protein is fused to a 8 amino acid His-Tag at C-terminus and purified by standard chromatography.

Source

Escherichia coli

Physical Appearance

Sterile filtered colorless solution.

Formulation

HMGN1 Human solution containing 20mM Trsi HCL pH-8, 1mM DTT, 0.1M NaCl, 0.1mM PMSF & 20% glycerol.

Stability

HMGN1 Human although stable at 4°C for 1 week, should be stored desiccated below -18°C. Please prevent freeze thaw cycles.

Amino acid sequence

MPKRKVSSAE GAAKEEPKRR SARLSAKPPA KVEAKPKKAA AKDKSSDKKV QTKGKRGAKG KQAEVANQET KEDLPAENGE TKTEESPASD EAGEKEAKSD LEHHHHHH

Usage

Bio-world products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

HMGB1 Human, HMGB1 Human, Hi-5