Human Goserelin

Human Goserelin

Source:

Background: Goserelin has actions similar to those of naturally occurring LHRH. LHRH released from the hypothalamus stimulates receptors on the pituitary gland, which then releases the gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Goserelin and other LHRH agonists provide a medical castration that deprives hormonally-dependent tumors of testosterone or estrogen. Normally, LHRH is released in a pulsatile manner to maintain levels of gonadotropins. Goserelin, in contrast, is continuously administered, which leads to downregulation of the LHRH receptor on the pituitary gland and decreased production of FSH and LH. During short-term or intermittent treatment, goserelin has the same stimulatory action as LHRH. This stimulation produces a surge of FSH and LH, which can cause a flare reaction in patients with prostate or breast carcinoma.

Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation: Lyophilized from a concentrated (1 mg/ml) solution in water containing no additives.

Solubility: It is recommended to reconstitute the lyophilized Goserelin in sterile 18MO-cm H2O not less than 100 g/ml, which can then be further diluted to other aqueous solutions.

Stability: Lyophilized Goserelin although stable at room temperature for 3 weeks, should be stored desiccated below -18 C. Upon reconstitution Goserelin should be stored at 4 C between 2-7 days and for future use below -18 C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.

Purity: Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Anion-exchange FPLC. (c) Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel.

Amino acid sequence: Glu-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-AzGly-NH2

Endotoxin: Less than 0.1 ng/ g (IEU/ g) of Goserelin.

Usage: BioWORLD\'s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.