Human MAGE-1 (Recombinant)

Recombinant Human Melanoma-Associated Antigen 1 (MAGE-1)

Source: E.Coli

Background: Human malignant neoplasms carry rejection antigens that are recognized by the patients autologous, tumor directed and specific, cytolytic, CD8+T lymphocyte clones (CTL). An important group of antigens is coded by the MAGE family of genes. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on mormal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.

Description: Recombinant Human MAGE1 produced in E.Coli is a disulfide-linked monomeric, non-glycosylated, polypeptide chain containing 200 amino acids and having a molecular mass of 22,756 Daltons. Recombinant Human MAGE-1 is purified by standard chromatographic techniques.

Formulation: 20 l purified human MAGE-1 protein at 100 g/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.

Application And Suggested Dilutions: ELISA Inhibition Assays Western Blotting

Characterization: MAGE-1 antibody reactive.

Storage & Stability: Store vial at -200C to -800C. When stored at the recommended temperature, this protein is stable for 12 months.

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