RAB27A, Member RAS Oncogene Family Human, Recombinant

Synonyms

GS2, RAM, RAB27, GS2, HsT18676, MGC117246, RAB27A, member RAS oncogene family.

RAB27A is part of the small GTPase superfamily, Rab family. RAB27A is membrane-bound and participates in protein transport and small GTPase mediated signal transduction. Mutations in this RAB27A are associated with Griscelli syndrome type 2. RAB27A is involved in cytotoxic granule exocytosis in lymphocytes.RAB27A is necessary for both granule maturation and granule docking and priming at the immunologic synapse.

Description

RAB27A Human Recombinant produced in E. coli is a single, non-glycosylated, polypeptide chain containing 241 amino acids (1-221a.a.) and having a molecular mass of 27 kDa. RAB27A protein is fused to a 20 amino acid His tag at N-terminus and is purified by standard chromatography.

Source

E. coli

Physical Appearance

Sterile filtered colorless solution.

Formulation

RAB27A Human solution containing 20mM Trsi HCL pH-8, 1mM DTT, & 20% glycerol.

Stability

RAB27A Human although stable at 4°C for 1 week, should be stored desiccated below -18°C. Please prevent freeze thaw cycles.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MSDGDYDYLI KFLALGDSGV GKTSVLYQYT DGKFNSKFIT TVGIDFREKR VVYRASGPDG ATGRGQRIHL QLWDTAGQER FRSLTTAFFR DAMGFLLLFD LTNEQSFLNV RNWISQLQMH AYCENPDIVL CGNKSDLEDQ RVVKEEEAIA LAEKYGIPYF ETSAANGTNI SQAIEMLLDL IMKRMERCVD KSWIPEGVVR SNGHASTDQL SEEKEKGACG C

Usage

Bio-world products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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