SARS Associated Spike Mosaic S(C) (Recombinant)

Recombinant SARS-Associated Coronavirus Spike mosaic S(C)

Source: E.Coli

Background: The spike (S) glycoprotein of coronaviruses mediates viral entry into host cells.Spike (S)-glycoprotein of the virus interacts with a cellular receptor and mediates membrane fusion to allow viral entry into susceptible target cells. It is a type 1 viral fusion protein that characteristically contains two heptad repeat regions, denoted HR-N and HR-C, that form coiled-coil structures within the ectodomain of the protein. Previous studies have shown that the two heptad repeat regions can undergo a conformational change from their native state to a 6-helix bundle (trimer of dimers), which mediates fusion of viral and host cell membranes.

Description: SARS-ACSM contains the C-terminal t section of the Spike protein immunodominant fragments, amino acids: (1051-1076), (1121-1154), (1162-1190) SARS-ACSM is purified by proprietary chromatographic techniques.

Purification method: Purified by proprietary chromatographic technique.

Purity: Recombinant SARS-ACSM is >95% pure as determined by 10% PAGE (coomassie staining) and RP-HPLC.

Formulation: 1mg/ml in 25 mM Tris-HCl, 0.4% sarcosyl, 0,25% Triton -100 and 50% glycerol

Storage: Recombinant SARS-ACSM is shipped at ambient temperature. Upon arrival, Store at -20C.

Stability: Recombinant SARS-ACSM is stable 5 years frozen, One month in solution at room temperature.

Specificity: Immunoreactive with sera of SARS-infected individuals

Application: Recombinant SARS-ACSM Antigen may be used in ELISA and Western blots, excellent for detection of SARS with minimal specificity problems.

Usage: BioWORLD\'s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.