Sincalide

Sincalide

Source:

Description: Sincalide also called CCK-8 has a molecular formula of C49H62N10O16S3 H-Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2 having a Mw of 1143.29. Sincalide corresponds to the C-terminal octapeptide of cholecystokinin (CCK) which acts on receptors within the gallbladder wall causing it to contract. Cholecystokinin (CCK) is a hormone originally isolated from porcine intestinal mucosa and described as a linear 33-amino acid peptide containing a sulfated tyrosine, which is essential for its biological activity. It has been found in mammals in both the digestive tract and the central nervous system. Among its multiple biological functions, this hormone stimulates pancreatic exocrine secretion, gallbladder contraction, and intestine motility and may also act as a neurotransmitter/neuromodulator in the central nervous system.

Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation: The Sincalide was lyophilized from a concentrated (1mg/ml) solution with no additives.

Solubility: It is recommended to reconstitute the lyophilized Sincalide in sterile 18MO-cm H2O not less than 100 g/ml, which can then be further diluted to other aqueous solutions.

Stability: Lyophilized Sincalide although stable at room temperature for 3 weeks, should be stored desiccated below -180C. Upon reconstitution Sincalide should be stored at 40C between 2-7 days and for future use below -180C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.

Purity: Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Mass Spectral Anaylsis {MALDI-TOF exhibits correct Mw}.

Usage: BioWORLD's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.