Colchicine

Antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

Synonyms: Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S)-;colchicine; 7-alpha-h-colchicine;7alpha-h-colchicine;acetamide, n-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(alpha)hepta;len-7- yl)-; n-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-acetamide; (s)-yl); n-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-acetamide; (s)-yl); benzo(a)heptalen-9(5h)-one;7-acetamido-6,7-dihydro-1,2,3,10-tetramethoxy-benzo(a)heptalen-9(5h)-one;colchicin;colchicina;colchicine;colchineos;colchisol;colcin;colsaloid;condylon; n-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamid;e; n-acetyl trimethylcolchicinic acid methylether; nsc 757

Light Sensitive

• Appearance: Yellow powder
• Boiling Point: 726.03 °C at 760 mmHg (Predicted)
• Density: 1.26 g/cm3 (Predicted)
• IUPAC_Name: N-R03;[(7S)-R03;1,R03;2,R03;3,R03;10-R03;Tetramethoxy-R03;9-R03;oxo-R03;5,R03;6,R03;7,R03;9-R03;tetrahydrobenzoR03;[a]R03;heptalen-R03;7-R03;yl]R03;acetamide
• Melting Point: 150-160 °C
• RTECS Number: GH0700000